Description
Description: CRMP-1 Human Recombinant (aa 448-568) expressed in E Coli, shows a 39 kDa band on SDS-PAGE (Including GST tag).The CRMP-1 is purified by proprietary chromatographic techniques.
Introduction: Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The X-ray crystal structure of murine CRMP1 was determined at 2.1 resolution and demonstrates that CRMP1 is a bilobed ˜lung-shaped' protein forming a tetrameric assembly